HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2305465Generated: October 25, 2026
1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178469560, compound
https://huagongshe.com/reaction/2305465
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Reactant | 2-{[3-(Trifluoromethyl)anilino]methylene}malonate | HCID 22648308 | — |
| Product | HCID 178469560 | HCID 178469560 | — |
Reaction Steps
Under a nitrogen atmosphere, a mixture of 2-{[3-(trifluoromethyl)anilino]methylene}malonate (80 g, 0.24 mol) and Dowtherm A was heated to 240° C. and then stirred for 3 hours. The reaction mixture was allowed to cool to ambient temperature and then stirred for 16 hours. The solids were isolated by filtration then washed with hexane to provide 47.5 g of ethyl 4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylate as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06440992B1 |
|---|
| Source dataset | uspto-grants-2002_08 |
|---|
| ORD ID | ord-a146791fecbb450b80b6d13a8ffc550d |
|---|
| Source note | uspto-grants-2002_08 |
|---|
