Carbon Dioxide → HCID 178516425, compound

HRID 2305467Notes

Reaction equation

HRID 2305467 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1C(O)=O.C(=O)=O>>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:7]=[C:6]2[C:11]([C:2]([OH:1])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 280Carbon DioxideHCID 178524718HCID 178524718, compound

Product 1

HCID 178516425HCID 178516425, compoundYield 98.6%

Procedure

A round bottom flask was charged with 4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylic acid (34.1 g, 0.132 mol) and then heated in a Wood's metal bath for 5 minutes during which time carbon dioxide evolution was observed and the material changed from a solid to a liquid. After 5 minutes no further gas evolution was noted so the flask was removed from the bath and allowed to cool to ambient temperature. The resulting solid was isolated by filtration to provide 27.75 g of 7-(trifluoromethyl)-4-quinolinol.

Workup

  1. customwas removed from the bath
  2. customThe resulting solid was isolated by filtration

Sources & evidence

ORD record
ord-dd6f4402ff554eb59c3d97d465116caf
Source dataset
uspto-grants-2002_08
Patent number
US06440992B1

Reaction notes

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