Ethanolamine → 2-[2-(4-Chloro-phenyl)-quinolin-4-ylamino]-ethanol hydrochloride

HRID 2305510Notes

Reaction equation

HRID 2305510 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1.[CH2:19]([CH2:21][NH2:22])[OH:20]>>[ClH:1].[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:3]=[C:2]([NH:22][CH2:21][CH2:19][OH:20])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 112195464-Chloro-2-(4-chlorophenyl)quinoline

Product 1

HCID 184331032-[2-(4-Chloro-phenyl)-quinolin-4-ylamino]-ethanol hydrochloride

Procedure

The title compound, m.p. 262-264° C., and MS: m/e=299.2 (M+H+), was prepared from 4-chloro-2-(4-chloro-phenyl)-quinoline and ethanolamine.

Sources & evidence

ORD record
ord-33990ed5f8ca4ba98a6d5a8aaf2f3c2b
Source dataset
uspto-grants-2002_08
Patent number
US06440995B1

Reaction notes

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