反应详情

162 mg of 2-fluoro-5-trifluoromethylphenylsulfonyl chloride in 6 ml of pyridine are added dropwise to a solution of 100 mg of 3-(4-aminophenyl)-1H-indole-2-carboxamide (example 1) in 12 ml of pyridine at 0° C. The mixture is stirred at ambient temperature for 6 hours and then poured into 50 ml of ice-cold water, and the precipitate formed is filtered off. After purification by flash chromatography on a silica column, elution being carried out with a mixture of cyclohexane and ethyl acetate (20/80 by volume), 50 mg of 3-[4-(2-fluoro-5-trifluoromethylbenzenesulfonylamino)phenyl]-1H-indole-2-carboxamide are obtained, the characteristics of which are as follows:

1. customthe precipitate formed
2. filtrationis filtered off
3. customAfter purification by flash chromatography
4. washon a silica column, elution
5. additionbeing carried out with a mixture of cyclohexane and ethyl acetate (20/80 by volume), 50 mg of 3-[4-(2-fluoro-5-trifluoromethylbenzenesulfonylamino)phenyl]-1H-indole-2-carboxamide
6. customare obtained