Prolinol, (R)- → HCID 69817091, compound

HRID 2305521Notes

Reaction equation

HRID 2305521 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH:3]=1.[NH:20]1[CH2:26][CH2:25][CH2:24][C@@H:21]1[CH2:22][OH:23]>CO>[ClH:1].[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:3]=[C:2]([N:20]3[CH2:26][CH2:25][CH2:24][C@@H:21]3[CH2:22][OH:23])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 2724541Prolinol, (R)-HCID 15481382HCID 15481382, compound

Product 1

HCID 69817091HCID 69817091, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound, m.p. 148-160° C., [α]D20=−62.6° (c=0.51, methanol) and MS: m/e=334 (M+), was prepared from 4-chloro-2-(4-methoxy-phenyl)-quinoline and D-prolinol.

Sources & evidence

ORD record
ord-43b597340ba74eb29f0b9b3d9fc776b6
Source dataset
uspto-grants-2002_08
Patent number
US06440995B1

Reaction notes

Loading…