(3S)-pyrrolidin-3-ol → HCID 69816764, compound

HRID 2305532Notes

Reaction equation

HRID 2305532 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH:3]=1.[OH:20][C@H:21]1[CH2:25][CH2:24][NH:23][CH2:22]1>>[ClH:1].[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:3]=[C:2]([N:23]3[CH2:24][CH2:25][C@H:21]([OH:20])[CH2:22]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 2733874(3S)-pyrrolidin-3-olHCID 15481382HCID 15481382, compound

Product 1

HCID 69816764HCID 69816764, compound

Procedure

The title compound, m.p. 270-271° C., MS: m/e=321.3 (M+H+), was prepared 4-chloro-2-(4-methoxy-phenyl)-quinoline and (S)-3-hydroxypyrrolidine.

Sources & evidence

ORD record
ord-e8994383030846f3aaadf9c825edfbc2
Source dataset
uspto-grants-2002_08
Patent number
US06440995B1

Reaction notes

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