Pyrrolidine → HCID 68826810, compound

Participants

Reaction Conditions

Reaction Steps

0.35 cm3 (4.174 mmol) of pyrrolidine is added, at a temperature in the region of 20° C., under an argon atmosphere, to 0.5 g (2.087 mmol) of 1-chloromethyl-2-nitro-4-trifluoromethylbenzene in solution in 20 cm3 of dichloromethane. After stirring for 16 hours at a temperature in the region of 20° C., the reaction mixture is diluted with 250 cm3 of dichloromethane, washed with 3 times 200 cm3 of water, dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness under reduced pressure (2.7 kPa), to give 458 mg of 1-(2-nitro-4-trifluoromethylbenzyl)pyrrolidine in the form of an oil;

Provenance & Evidence