反应详情

3-hydroxy-4nitrophenylacetic acid (1.1 g) was refluxed in methanol (20 ml) containing 0.5 ml of conc. sulphuric acid for 4 hrs., diluted with water and extracted with diethyl ether. The organic layer was separated, washed with aqueous sodium bicarbonate, brine, dried and then evaporated to dryness to give methyl 3-hydroxy-4-nitrophenylacetate (1.2 g) as a gum which crystallised on standing.

1. extractionextracted with diethyl ether
2. customThe organic layer was separated
3. washwashed with aqueous sodium bicarbonate, brine
4. customdried
5. customevaporated to dryness