Methanol → HCID 18433366, compound

HRID 2305620Notes

Reaction equation

HRID 2305620 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].S(=O)(=O)(O)O.[CH3:20]O>O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([O:14][CH3:20])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 235083252-(3-Hydroxy-4-nitrophenyl)acetic acid

Product 1

HCID 18433366HCID 18433366, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-hydroxy-4nitrophenylacetic acid (1.1 g) was refluxed in methanol (20 ml) containing 0.5 ml of conc. sulphuric acid for 4 hrs., diluted with water and extracted with diethyl ether. The organic layer was separated, washed with aqueous sodium bicarbonate, brine, dried and then evaporated to dryness to give methyl 3-hydroxy-4-nitrophenylacetate (1.2 g) as a gum which crystallised on standing.

Workup

  1. extractionextracted with diethyl ether
  2. customThe organic layer was separated
  3. washwashed with aqueous sodium bicarbonate, brine
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-0198d455d3b0424286f0615f845cd24a
Source dataset
uspto-grants-2002_08
Patent number
US06441012B1

Reaction notes

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