HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2305625Generated: November 2, 2026
Hydrochloric Acid → 3-Benzyloxy-5-methoxy-4-nitrophenol
https://huagongshe.com/reaction/2305625
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Benzyl 5-fluoro-3-methoxy-2-nitrophenyl ether | HCID 18433397 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Benzyloxy-5-methoxy-4-nitrophenol | HCID 18433396 | — |
Reaction Steps
A mixture of 3-benzyloxy-5-fluoro-2-nitroanisole(0.75 g), dimethylsulphoxide(5 mL) and 5N aqueous sodium hydroxide(2 mL) was stirred at 70° C. for 3 h. The mixture was diluted with water and acidified with concentrated hydrochloric acid, extracted with ethyl acetate and the extract was washed with water dried and evaporated to dryness to give the product (0.71 g), (m/e274, MH−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06441012B1 |
|---|
| Source dataset | uspto-grants-2002_08 |
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| ORD ID | ord-f8c7bd2909f44732920f04a57e0e0e42 |
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| Source note | uspto-grants-2002_08 |
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