Sodium Hydroxide → 3,5-Difluoro-2-nitrophenol

Participants

Reaction Steps

A solution of 2,4,6-trifluoronitrobenzene (10 g) in dimethyl sulphoxide(50 mL) was treated with 10N sodium hydroxide(12 mL) and the mixture was stirred at room temperature for 18 h. The mixture was diluted with water and washed with ether. The aqueous phase was then acidified and extracted with ether. The extract was washed with brine, dried and evaporated to dryness and the residue was purified by flash chromatography eluting with increasingly polar mixtures of ethyl acetate and hexane to give the product(8.3 g) [m/e 174, MH−].

Provenance & Evidence