Methanol → HCID 18433362, compound

HRID 2305639Notes

Reaction equation

HRID 2305639 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:18]([CH3:22])[C:19]([OH:21])=[O:20])[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:28]O>>[CH3:28][O:20][C:19](=[O:21])[CH:18]([C:11]1[CH:12]=[CH:13][C:14]([N+:15]([O-:17])=[O:16])=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)[CH3:22]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 18433377HCID 18433377, compound

Product 1

HCID 18433362HCID 18433362, compound

Procedure

A mixture of 2-(3-benzyloxy4-nitrophenyl)propionic acid(1.89 g), methanol(30 mL) and concentrated sulphuric acid(1 mL) was heated at reflux for 3 h, cooled to ambient temperature and the mixture was extracted with ether. The extract washed with brine, dried and evaporated to dryness to give methyl-2-(3-benzyloxy-4-nitrophenyl)propionate(1.8 g). [m/e316(MH+)].

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 h
  3. extractionthe mixture was extracted with ether
  4. washThe extract washed with brine
  5. customdried
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-13e0c94980804af3a9af21c82540b281
Source dataset
uspto-grants-2002_08
Patent number
US06441012B1

Reaction notes

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