反应详情

温度

0 °C

A suspension of 2.57 g (12.53 mmol) of 7-nitro-1H-indole-2-carboxamide in 35 ml of pyridine is cooled to 0° C. in a water/ice bath. A solution of 4.01 g (12.53 mmol) of pyridinium tribromide in 20 ml of pyridine is then added at 0° C. dropwise, and the reaction is then stirred at 0° C. for 30 minutes and at ambient temperature for 16 h. 70 ml of ice-cold water are then added to the reaction medium. The latter is then stirred at ambient temperature for 15 minutes and is then filtered over sintered glass, to give 2.81 g of 3-bromo-7-nitro-1H-indole-2-carboxamide in the form of a brown solid.

1. stirringThe latter is then stirred at ambient temperature for 15 minutes
2. filtrationis then filtered over sintered glass