反应详情

3.28 g of palladium-on-charcoal are added to a suspension of 3.42 g (6.82 mmol) of 3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-7-nitro-1H-indole-2-carboxamide in 480 ml of methanol. The reaction mixture is hydrogenated at 30° C. under 3 bar for 2 h in an autoclave, and is then filtered over yridi. The filtrate is evaporated to dryness under reduced pressure. The residue obtained is triturated with ethyl acetate and a small amount of methylene chloride and then filtered. 1.30 g of 7-amino-3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-1H-indole-2-carboxamide are obtained in the form of a gray solid.

1. filtrationis then filtered over yridi
2. customThe filtrate is evaporated to dryness under reduced pressure
3. customThe residue obtained
4. customis triturated with ethyl acetate
5. filtrationa small amount of methylene chloride and then filtered