反应详情

To a solution of 3-(3-pyridyloxy)propylamine (0.354 g, 2.30 mmol) in ethanol (5 mL) was added galactaric acid (0.244 g, 1.16 mmol). Water (1.5 mL) was added drop-wise, while warming the solution to reflux. To remove some white, insoluble solids, the warm solution was filtered through a glass wool plug, washing the filter plug with a warm solution of ethanol-water (4:1, v/v). The filtrate was diluted with ethanol (25 mL). The mixture was allowed to cool to ambient temperature and was further cooled at 5° C. for 16 h. The solids were filtered, washed with cold ethanol (5 mL), and vacuum dried at 40° C. to give 344.8 mg (58.3%) of light-yellow crystals, mp 176-178° C. The compound exhibits a Ki of 65 nM; the effect at muscle sites is 0 percent; and the effect at ganglia sites is 0 percent. The compound exhibits a Ki of 12 nM; the effect at muscle sites is 0 percent; and the effect at ganglia sites is 0 percent. The compound exhibits neurotransmitter release of 0 percent.

1. temperaturewhile warming the solution
2. temperatureto reflux
3. customTo remove some white, insoluble solids
4. filtrationthe warm solution was filtered through a glass wool plug
5. washwashing the filter plug with a warm solution of ethanol-water (4:1
6. additionThe filtrate was diluted with ethanol (25 mL)
7. temperaturewas further cooled at 5° C. for 16 h
8. filtrationThe solids were filtered
9. washwashed with cold ethanol (5 mL), and vacuum
10. customdried at 40° C.