HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 230571Generated: October 27, 2026
Aluminum(III) Chloride → 1-(4-Chloro-2-hydroxyphenyl)ethanone
https://huagongshe.com/reaction/230571
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone | HCID 57762881 | — |
| Product | 1-(4-Chloro-2-hydroxyphenyl)ethanone | HCID 1051513 | — |
Reaction Steps
3-chlorophenyl acetate (starting material 2) was mixed with aluminium chloride (3 eq). The mixture was heated at 200° C. for 1 hour. The reaction medium was cooled to room temperature then poured in ice. The aqueous phase was extracted with methylene chloride which was dried on magnesium sulfate then vacuum evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07566737B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-2dd3cc31c5c841f7bbcf611a0e989be6 |
|---|
| Source note | uspto-grants-2009_07 |
|---|
