HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylcyclopropanecarboxylic acid → HCID 86758483, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylcyclopropanecarboxylic acid | HCID 81326 | — |
| Reactant | (1R)-1-(naphthalen-2-yl)ethan-1-amine | HCID 1798835 | — |
| Product | HCID 86758483 | HCID 86758483 | 76% |
Reaction Steps
Similarly to Example 1d), 1.5 g (15 mmol) of 1-methylcyclopropane-1-carboxylic acid were reacted with 2.6 g (15 mmol) of (1R)-1-naphth-2-ylethylamine to give the title compound. The product was isolated, after purification by silica gel chromatography (mobile phase: cyclohexane/ethyl acetate gradient), as a white solid (2.9 g; 76% yield, melting point 91° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06441044B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-c8fa809c3c654bd1b922830bef877f2b |
| Source note | uspto-grants-2002_08 |