4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

HRID 2305848Notes

Reaction equation

Br[CH:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([S:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH3:7]

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 95580Ethyl 2-bromooctanoate

Product 1

HCID 114383212-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

Procedure

2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from ethyl 2-bromooctanoate (11.8 g, 47.3 mmol) and 4-methoxythiophenol (6 g, 43 mmol). Yield: 7.24 g (57%); clear oil; MS: 311.2 (M+H)+.

Sources & evidence

ORD record: ord-38bf73ddc0694cf0a44d0b9d21797a66
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06441023B1

Reaction notes

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