2-(Chloromethyl)-1,1'-biphenyl → 3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)propionic acid ethyl ester

참여 물질

반응 단계

3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-methyl-(1-methyl-1H-imidazolesulfonyl)-propionic acid ethyl ester Prepared from (1-Methyl-2-mercapto imidazole and 2-bromo ethyl propionate) (3.0 g, 12.2 mmol) and 4 chloromethylbiphenyl (2.97 g,15 mmol). Yield 5.0 g (99 %); low melting solid; MS 413 (M+H)+.

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