1-Bromo-2-butyne → HCID 70147290, compound

Participants

Reaction Steps

2-(4-Fluoro-benzenesulfonyl)-2-but-2-ynylhexynoic acid tert-butyl ester was prepared according to the procedure as outlined in Example 9. aSctarting from 2-(4fluoro-benzenesulfonyl)-acetic acid tert-butyl ester (4.87 g, 20 mmol) and 1-bromo-2-butyne (5.36 g, 40 mmol), 6.0 g of the product was isolated. Yield 77%; white solid; mp 85° C.; MS: 379.1 (M+H)+.

Provenance & Evidence