HCID 11103550, compound → HCID 10929367, compound

Participants

Reaction Steps

4-(4-Methoxy-benzenesulfonyl)-1-[4-(2-piperidin- 1-yl-ethoxy)-benzyl]-piperidine-4-carboxylic acid was prepared starting from 4-(4-Methoxy-benzenesulfonyl)-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-piperidine-4-carboxylic acid ethyl ester (5.4 g, 10 mmol) dissolved in TBF:methanol 3:1 and 10 N NaOH (40 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 4.0 g (77%); off white powder, mp 174° C.; MS: 517.6 (M+H)+.

Provenance & Evidence