反应详情

To a solution of ethyl 5-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-[(methylsulfonyl)amino]benzoate (4.3 g,11 mmol) in methanol (30 ml) was added hydrogenchloride-methanol solution (30 ml). The solution was stirred at room temperature for 30 minutes and then concentrated under reduced pressure. The given residue was recrystallized from methanol-diethyl ether. The precipitate was then filtered, washed with diethyl ether and collected to furnish 3.1 g (87% yield) of the title compound as a white solid.

1. concentrationconcentrated under reduced pressure
2. customThe given residue was recrystallized from methanol-diethyl ether
3. filtrationThe precipitate was then filtered
4. washwashed with diethyl ether
5. customcollected