Sodium sulfate decahydrate → N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-(hydroxymethyl)phenyl]methanesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a mixture of lithium alminium hydride (1.6 g, 43 mmol) in tetrahydrofuran (THF) (50 ml) was added a solution of ethyl 5-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-[(methylsulfonyl)amino]benzoate (4.2 g, 11 mmol) in tetrahydrofuran (THF) (100 ml) at 0° C. After being stirred for 3 hours at 0° C., potassium fluoride and sodium sulfate decahydrate were added. After being stirred for 5 hours, the reaction mixture was filtered and the filtrate was evaporated under reduced pressure to give 3.6 (97% yield) of the title compound as slightly yellow oil. MS (ESI) m/z 391 [M+H]+, 389 [M−H]−.

Provenance & Evidence