HCID 53876130, compound → HCID 18416806, compound

HRID 2305928Notes

Reaction equation

HRID 2305928 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH:8]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:7]1)=[O:5])C>C1COCC1.CO.[OH-].[Na+]>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([CH2:23][O:22][C:19]2[CH:18]=[CH:17][C:16]([S:13]([CH:8]3[CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:11][CH2:10][N:9]3[CH3:12])(=[O:15])=[O:14])=[CH:21][CH:20]=2)=[CH:29][CH:28]=1

Participants

4

Reactant 1

HCID 53876130HCID 53876130, compound

Product 1

HCID 18416806HCID 18416806, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

[4-(4-Chloro-benzyloxy)-benzenesulfonyl-1-methylpiperidine-4-carboxylic acid was prepared starting from [4-(4-Chloro-benzyloxy)-benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid ethyl ester (10.7 g, 24 mmol) dissolved in THF:Methanol (75: 75 mI) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 4.9 g (50%); off white solid; MS: 426.2 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-998ebf82f6a947318aa6b3cfbaca58b2
Source dataset
uspto-grants-2002_08
Patent number
US06441023B1

Reaction notes

Loading…