Sodium Hydroxide → HCID 18416700, compound

HRID 2305932Notes

Reaction equation

HRID 2305932 reaction equation
C([O:3][C:4]([C:6]1([S:19]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:24][CH:23]=2)(=[O:21])=[O:20])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+]>CO>[CH2:29]([O:28][C:25]1[CH:26]=[CH:27][C:22]([S:19]([C:6]2([C:4]([OH:5])=[O:3])[CH2:7][CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:10][CH2:11]2)(=[O:20])=[O:21])=[CH:23][CH:24]=1)[CH2:30][CH2:31][CH3:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57186700HCID 57186700, compound

Product 1

HCID 18416700HCID 18416700, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-Butoxy-benzenesulfonyl)-1-pyridin-4-ylmethyl-piperidine-4-carboxylic acid was prepared starting from 4-(4-Butoxy-benzenesulfonyl)-1-pyridin-4-ylmethyl-piperidine-4-carboxylic acid ethyl ester (3.0 g, 6.5 mmol) dissolved in TBF:Methanol (75: 50 ml) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 1.2 g (42%); off white solid; MS: 433.0 (M+H)+

Workup

  1. dissolutiondissolved in TBF
  2. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-0f557e6d725a4e23a403996965cb469e
Source dataset
uspto-grants-2002_08
Patent number
US06441023B1

Reaction notes

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