Boron tribromide → HCID 18433431, compound

Participants

Reaction Steps

3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)-phenoxy]-benzonitrile was prepared from 3,5-dichloro-4-[4-methoxy-3-(piperidine-1-carbonyl)-phenoxy]-benzonitrile according to a procedure analogous to that described in EXAMPLE 2, Step B. Boron tribromide (1M in dichloromethane, 2.0 equiv) was used. After water addition, the mixture was stirred for 30 minutes at RT, then basified with aqueous saturated sodium bicarbonate solution, and extracted with dichloromethane (3×10 ml). The combined organic phases were dried over anhydrous Na2SO4, filtered, and concentrated. The title product of Step E was used in the next step without purification.) MS (APCI+) Calc.: 390.0, Found: 391.1 (M+1).

Provenance & Evidence