反应详情

A thionyl chloride (25 ml) solution of 2-(2,6-difluoro-4-methoxyphenyl)-1,1,1-trifluoropropan-2-ol (8.7 g, 34.1 mmol) and pyridine (26 mg, 0.34 mmol) was stirred at 70° C. for 3 hours. Then, the reaction was concentrated in vacuo and diluted with water. The product was extracted with hexane and the organic layer was dried over sodium sulfate, filtered and concentrated to furnish 8.84 g (94% yield) of the title compound as a colorless oil.

1. concentrationThen, the reaction was concentrated in vacuo
2. additiondiluted with water
3. extractionThe product was extracted with hexane
4. dry with materialthe organic layer was dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated