反应详情

A mixture of 1,3-difluoro-5-methoxy-2-(2,2,2-trifluoro-1,1-dimethylethyl)benzene (7.93 g, 31.2 mmol) and 1 M dichloromethane solution of boron tribromide (150 ml, 150 mmol) was stirred at room temperature for 16 hours. Then, the reaction was quenched with water and the product was extracted with ethyl acetate which was dried over sodium sulfate. Then, filtration, evaporation, purification by silica gel column chromatography, eluting with hexane/ethy lacetate (10:1), furnished 7.79 g (quant.) of the title compound as a brown solid.

1. customThen, the reaction was quenched with water
2. extractionthe product was extracted with ethyl acetate which
3. dry with materialwas dried over sodium sulfate
4. filtrationThen, filtration, evaporation, purification by silica gel column chromatography
5. washeluting with hexane/ethy lacetate (10:1)