Thionyl Chloride → 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride

HRID 2306005Notes

Reaction equation

HRID 2306005 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:10]=3[CH:11]=[CH:12][CH:13]=[N:14]4)[N:7]=[CH:6][C:5]=2[C:19]([OH:21])=O)[CH2:3][CH2:2]1.S(Cl)([Cl:24])=O>C1(C)C=CC=CC=1>[CH:1]1([C:4]2[N:8]([C:9]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:10]=3[CH:11]=[CH:12][CH:13]=[N:14]4)[N:7]=[CH:6][C:5]=2[C:19]([Cl:24])=[O:21])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 113004451H-Pyrazole-4-carboxylic acid, 5-cyclopropyl-1-(5-quinolinyl)-

Product 1

HCID 112318115-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

combining 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carboxylic acid and thionyl chloride in toluene to form 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carboxylic acid chloride; and

Sources & evidence

ORD record
ord-39d69625f95141dba569e5e03623693b
Source dataset
uspto-grants-2002_08
Patent number
US06441176B1

Reaction notes

Loading…