Sodium Hydroxide → 1H-Pyrazole-4-carboxylic acid, 5-cyclopropyl-1-(5-quinolinyl)-

HRID 2306006Notes

Reaction equation

HRID 2306006 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[N:7][N:8]([C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[CH:15]=[CH:16][CH:17]=[N:18]3)[C:9]=1[CH:10]1[CH2:12][CH2:11]1)=[O:4].[OH-].[Na+]>CO>[CH:10]1([C:9]2[N:8]([C:13]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:14]=3[CH:15]=[CH:16][CH:17]=[N:18]4)[N:7]=[CH:6][C:5]=2[C:3]([OH:4])=[O:2])[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11449248Methyl 5-cyclopropyl-1-(5-quinolyl)pyrazole-4-carboxylate

Product 1

HCID 113004451H-Pyrazole-4-carboxylic acid, 5-cyclopropyl-1-(5-quinolinyl)-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

hydrolyzing the 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carboxylic acid methyl ester with methanol in the presence of sodium hydroxide at reflux to form 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carboxylic acid;

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-69052b2e3baf45d1b66dbdbf4d097a8f
Source dataset
uspto-grants-2002_08
Patent number
US06441176B1

Reaction notes

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