Thionyl Chloride → 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride

HRID 2306007Notes

Reaction equation

[CH:1]1([C:4]2[N:8]([C:9]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:10]=3[CH:11]=[CH:12][CH:13]=[N:14]4)[N:7]=[CH:6][C:5]=2[C:19]([OH:21])=O)[CH2:3][CH2:2]1.S(Cl)([Cl:24])=O>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:10]=3[CH:11]=[CH:12][CH:13]=[N:14]4)[N:7]=[CH:6][C:5]=2[C:19]([Cl:24])=[O:21])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 113004451H-Pyrazole-4-carboxylic acid, 5-cyclopropyl-1-(5-quinolinyl)-

Product 1

HCID 112318115-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride

Procedure

combining 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carboxylic acid and thionyl chloride to form 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carboxylic acid chloride;

Sources & evidence

ORD record: ord-836ed642e12946d5a6ce5608151c6d21
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06441176B1

Reaction notes

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