3-Hydroxybenzaldehyde → 3-Propoxybenzaldehyde

Participants

Reaction Steps

For example, (E)-3-(3′-propyloxyphenyl)-2-propenoyl chloride, used in Example 3 (i), can be prepared from commercially available 3-hydroxybenzaldehyde by reacting 3-hydroxybenzaldehyde with 1-iodopropane to give 3-propyloxy benzaldehyde. 3-Propyloxy benzaldehyde is then reacted with malonic acid to give the corresponding propenonic acid which is subsequently converted into (E)-3-(3′-propyloxyphenyl)-2-propenoyl chloride by reaction with oxalyl chloride.

Provenance & Evidence