Potassium Hydroxide → HCID 9968310, compound

Participants

Reaction Steps

A mixture of Example 3F in ethanol (300 mL) was treated with a solution of 30% (w/w) KOH in water (100 mL), heated to reflux, stirred for 8 hours, treated with additional 30% KOH in water (5 mL), stirred for 40 minutes, cooled to room temperature, concentrated to a slurry, and extracted with toluene. The extract was washed with 1M NaOH and brine, dried (Na2SO4), filtered, and concentrated to provide 48.6 g of the desired product. 1H NMR (300 MHz, DMSO-d6) δ7.45 (m, 2H), 7.33 (m, 5H), 6.90 (m, 2H), 6.67 (d, 1H, J=5 Hz), 4.63 (s, 2H), 3.95 (m, 2H), 3.08 (m, 1H), 2.73 (m, 1H), 2.62 (m, 1H), 1.40 (br s, 2H).

Provenance & Evidence