Triethylamine → HCID 21257617, compound

Participants

Reaction Steps

2″,7″-[Bis-(4β-N-podophyllotoxin)] diaminoflourene (8a) was prepared by the same method described earlier, employing 2,7-diamino flourene (135 mg, 0.5 mmol), Bu4N+I−(185 mg, 0.5 mmol) and Et3N (150 mg, 1.5 mmol) and 4β-bromo podophyllotoxin (476 mg, 1.0 mmol) to give 8a in 75% yield. Spectral data: 1H NMR (CDCl3); 7.39-7.50 (d, 2H), 6.82 (S, 2H), 6.68 (S, 2H), 6.45-6.58 (br, 4H), 6.31 (S, 4H), 5.92-6.01 (ABq, 4H), 4.71 (br, 2H), 4.60 (d, 2H), 4.38-4.48 (t, 2H), 4.00-4.13 (t, 2H), 3.80 (d, 18H), 3.10-3.22 (dd, 2H), 2.90-3.10 (m 2H); FAB MS: mn/z 988 (M+); mp. 215-218° C.

Provenance & Evidence