Triethylamine → HCID 21257617, compound

Participants

Reaction Steps

2″,7″-[Bis-(4′-O-demethylA4β-N-4-desoxypodophyllotoxin)] diamino flourene (8b) was prepared according to the procedure described for the earlier compounds, employing 2,7-diamino flourene (135 mg, 0.5 mmol), Bu4N+I−(185 mg, 0.5 mmol), Et3N (150 mg, 1.5 mmol) and 4′-O-demethyl-4β-bromo podophyllotoxin (462 mg, 1.0 mmol) to give the product in 70% yield. Spectral data: 1H NMR (CDCl3); 7.39-7.45 (d, 2H), 6.78 (S, 2H), 6.66 (S, 2H), 6.50 (S, 2H), 6.43-6.48 (d, 2H), 6.30 (S, 4H), 5.92-6.00 (ABq, 4H), 5.33 (S, 2H), 4.70 (br, 2H), 4.55-4.61 (d, 2H), 4.334.45 (t, 2H), 3.97-4.10(t,2H), 3.79 (S, 6H), 3.08-3.20 (dd, 2H), 2.90-3.08 (m, 2H); FAB MS: m/z 960 (M+); mp. 240-243° C.

Provenance & Evidence