HCID 10982168, compound → HCID 10881328, compound

Participants

Reaction Steps

To a solution of (R)-1-(3-benzyloxybenzyl)-3-(tert-butoxycarbonylamino)-2-oxopyrrolidine, as described above in Step L, (500 mg, 1.26 mmol) in EtOH (75 mL) was added 20% Pd(OH)2 on carbon (75 mg) and the reaction mixture was stirred under an atmosphere of hydrogen (ca. 1 atm) at ambient temperature for 18 hours. The mixture was filtered through a pad of celite, washing with EtOH, and the filtrate was concentrated in vacuo to give a crude product. This was purified by flash column chromatography on silica, eluting with CHCl3—3% MeOH—0.3% NH4OH, to yield the titled product as a colorless oil.

Provenance & Evidence