Hydrochloric Acid → HCID 18433560, compound

Participants

Reaction Steps

A solution of 4-bromo-1-tert-butoxycarbonylaminonaphth-7-yl methanesulfonate, as described above in Step B, (2.00 g, 4.80 mmol) in THF (50 mL) and 10% aqueous NaOH (85 mL) was heated to 65° C. for 60 hours. The cooled mixture was adjusted to pH of about 7 by addition of conc. aqueous HCl and concentrated to dryness under reduced pressure to provide the desired phenol.

Provenance & Evidence