Lawesson's reagent → HCID 88191236, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-3-(tert-butoxycarbonylamino)-1-[7-(tert-butyl-dimethylsilyloxy)naphthalen-1-yl]-2-oxopyrrolidine, as described above in Step F, (113 mg, 0.247 mmol) and Lawesson's Reagent (50 mg, 0.124 mmol) in dry toluene (0.5 mL), under argon, was heated to 80° C. for 1 hour. The reaction mixture was allowed to cool, then poured directly onto a silica gel column and chromatographed, eluting with a gradient of hexane—5% to 25% EtOAc to yield the titled product as a clear oil.

Provenance & Evidence