HCID 11094084, compound → HCID 11814778, compound

Participants

Reaction Steps

A mixture of (S)-N-{1-[7-(tert-butyldiphenylsilyloxy)naphthalen-1-yl]-2-oxopyrrolidin-3-yl}-2-[1-(triphenylmethyl)-1H-imidazol-4-yl]thioacetamide, as described above in Step E, (1.85 g, 2.18 mmol) and Raney Ni (3.7 g of a slurry in EtOH) was stirred in MeOH (80 mL) at 35° C. for 5 hours. The mixture was filtered through a pad of celite, washing with MeOH, and the filtrate was concentrated to provide the titled product as a foam.

Provenance & Evidence