Tetrabutylammonium Fluoride → HCID 11813797, compound

Participants

Reaction Steps

To a stirred solution of (S)-{1-[7-(tert-butyldiphenylsilyloxy)naphthalen-1-yl]-2-oxo-pyrrolidin-3-yl}-{2-[3-(4-cyano-3-fluorobenzyl)-3H-imidazol-4-yl]ethyl}carbamic acid tert-butyl ester, as described above in Step I, (500 mg, 0.619 mmol) in ThF (5 mL) was added TBAF (0.68 mL of a 1 M solution in THF, 0.68 mmol), dropwise. The mixture was stirred at ambient temperature for 30 min, then concentrated in vacuo. The residue was purified by flash column chromatography on silica, eluting with CHCl3—2% MeOH—0.2% NH4OH to yield the desired phenol as a white foam.

Provenance & Evidence