HCID 178500033, compound → HCID 178500034, compound

Participants

Reaction Steps

To a solution of methyl 3-(imidazol-4-yl)acrylate hydrochloride, as described above in Step A, (500 mg, 2.65 mmol) in EtOH (100 mL) was added 10% Pd on carbon (250 mg) and the reaction mixture was shaken under an atmosphere of hydrogen (45 psi) at ambient temperature for 18 hours on a Parr hydrogenation apparatus. The mixture was filtered through a pad of celite, washing with EtOH, and the filtrate was filtered through a pad of celite, washing with EtOH, and the filtrate was concentrated in vacuo to give the titled product.

Provenance & Evidence