Azobisisobutyronitrile → HCID 18536041, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methanesulfonic acid 4-bromo-3-methylphenyl ester, as described above in Step B, (14.3 g, 53.9 mmol), N-bromosuccinimide (14.4 g, 80.9 mmol), and 2,2′-azobisisobutyronitrile (1.34 g, 8.16 mmol) in CCl4 was heated at 80° C. for 18 hours. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography, eluting with a gradient of hexane—5% to 20% EtOAc, to yield the titled product.

Provenance & Evidence