Trifluoroacetic acid → HCID 131723468, compound

Participants

Reaction Conditions

Reaction Steps

(S)-3-(tert-Butoxycarbonylamino)-1-[3′-(tert-butyldimethylsilyloxy) biphen-2-yl]-2-oxopyrrolidine, as described above in Step E, (888 mg, 1.84 mmol) was dissolved in CH2Cl2 (20 mL), cooled to 0° C., and trifluoroacetic acid (4 mL) was added. After 3 hours, the reaction mixture was poured into saturated aqueous NaHCO3 and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo, to yield the above-titled compound.

Provenance & Evidence