HCID 18433622, compound → HCID 18433566, compound

Participants

Reaction Steps

3-(tert-Butyldimethylsilyloxy)-5-nitroquinoline, as described above in Step E, (4.58 g, 15.04 mmol) was dissolved in EtOH (150 mL) and EtOAc (150 mL), the vessel was degassed, Pd/C (0.458 g, 10 wt %) was added and the mixture was subjected to H2 (1 atm) with vigorous stirring for 1 hour. The mixture was filtered through a celite pad and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with a gradient of 0% to 10% EtOAc in CH2Cl2, to yield the above-titled compound.

Provenance & Evidence