HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 8-Nitroquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl 2-acetamido-3-nitrocinnamate | HCID 70171492 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 8-Nitroquinolin-2(1H)-one | HCID 346520 | — |
Reaction Steps
Methyl 2-acetamido-3-nitrocinnamate, as described above in Step B, (5.76 g, 21.8 mmol) was dissolved in 3 N aqueous HCl (220 mL) and the solution was heated at reflux for 72 hours, cooled, neutralized with NaHCO3 and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo, to yield the above-titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06441017B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-a8f29881f4a041aea23c6dec57606354 |
| Source note | uspto-grants-2002_08 |