反应详情

2-Methoxy-8-nitroquinoline, as described above in Step D, (2.07 g, 10.14 mmol) was dissolved in EtOH (150 mL) and EtOAc (150 mL), the vessel was degassed, Pd/C (200 mg, 10 wt %) was added and the vessel was filled with H2 (1 atm). After 1 hour, the reaction was filtered through a pad of celite and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with CH2Cl2, to yield the above-titled compound.

1. customEtOAc (150 mL), the vessel was degassed
2. additionPd/C (200 mg, 10 wt %) was added
3. additionthe vessel was filled with H2 (1 atm)
4. filtrationthe reaction was filtered through a pad of celite
5. concentrationconcentrated in vacuo
6. customThe residue was chromatographed on silica gel
7. washeluting with CH2Cl2