Hydrochloric Acid → tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate

Participants

Reaction Steps

To a stirred solution of (S)-1-(tert-butoxycarbonyl)-3-(trifluoro-acetamido)pyrrolidine, as described above in Step A, (2.80 g, 9.5 mmol) in THF (80 mL) and H2O (10 mL) was added 1.0 N aqueous lithium hydroxide (10.5 mL, 10.5 mmol) and the resulting mixture was stirred at ambient temperature for 18 hours, then adjusted to pH 7 with 1.0 N aqueous HCl and concentrated to dryness in vacuo to give the titled compound.

Provenance & Evidence