1,2-Dichloroethane → HCID 70171956, compound

Participants

Reaction Steps

A mixture of (S)-3-amino-1-(tert-butoxycarbonyl)pyrrolidine, as described above in Step B, (842 mg, 4.52 mmol), lithium [1-(triphenylmethyl)-1H-imidazol-4-yl]acetate, as described in Example 31, Step B, (1.69 g, 4.52 mmol), EDC (953 mg, 4.97 mmol), HOBT (672 mg, 4.97 mmol) and N,N-diisopropylethylamine (1.2 mL, 6.78 mmol) in DMF (10 mL) was stirred for 18 hours. The mixture was poured into saturated aqueous NaHCO3 and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with a gradient of CH2Cl2—1% to 5% MeOH—0.1% to 0.5% NH4OH, to yield the above-titled compound.

Provenance & Evidence