Trifluoroacetic acid → HCID 70171489, compound

Participants

Reaction Steps

(S)-N-[1-(tert-Butoxycarbonyl)pyrrolidin-3-yl]-N-{2-[1-(4-cyano-3-fluorobenzyl)-1H-imidazol-5-yl]ethyl}carbamic acid triisopropylsilyl ester, as described above in Step G, (395 mg, 0.643 mmol) was dissolved in CH2Cl2 (10 mL) and TFA (2 mL, 2.56 mmol) was added. After 2 hours, the reaction was neutralized with triethylamine, diluted with water and extracted with CH2Cl2 (3×). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo, to yield the above-titled compound.

Provenance & Evidence