Hydrochloric Acid → HCID 18433604, compound

Participants

Reaction Steps

To a stirred solution of 2-bromo-1-(tert-butoxycarbonylamino)naphth-7-yl methanesulfonate, as described above in Step E, (5.87 g, 14.09 mmol) in DMSO (70 mL) was added potassium tert-butoxide (5.17 g, 42.27 mmol) in one portion. The reaction mixture was stirred at ambient temperature for 1 hour, then neutralized with aqueous HCl, diluted with water and extracted with Et2O (2×). The combined organic extracts were washed with water (3×), dried over Na2SO4, filtered and concentrated in vacuo, to yield the above-titled compound.

Provenance & Evidence