Trifluoroacetic acid → HCID 18433517, compound

Participants

Reaction Steps

To a solution of 2-bromo-1-(tert-butoxycarbonylamino)-7-(tert-butyldimethylsilyloxy)naphthalene, as described above in Step G, (6.0 g, 13.26 mmol) in CH2Cl2 (100 mL) at 0° C. was added TFA (10 mL). After 45 min, the mixture was poured into saturated aqueous NaHCO3 and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with a gradient of hexane—5% to 20% CH2Cl2, to yield the above-titled product.

Provenance & Evidence